5VU0

Crystal structure of the complex between afucosylated/galactosylated human IgG1 Fc and Fc gamma receptor IIIa (CD16A) with Man5 N-glycans

Summary for 5VU0

• Entry DOI: 10.2210/pdb5vu0/pdb
• Descriptor: Immunoglobulin gamma-1 heavy chain, Low affinity immunoglobulin gamma Fc region receptor III-A, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: complex, glycosylated, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 73095.36

Authors

Subedi, G.S.,Marcella, A.M.,Barb, A.W. (deposition date: 2017-05-18, release date: 2018-05-23, Last modification date: 2023-10-04)

• Primary citation: Falconer, D.J.,Subedi, G.P.,Marcella, A.M.,Barb, A.W.; Antibody Fucosylation Lowers the Fc gamma RIIIa/CD16a Affinity by Limiting the Conformations Sampled by the N162-Glycan.; ACS Chem. Biol., 13:2179-2189, 2018; PubMed: 30016589; DOI: 10.1021/acschembio.8b00342

Experimental method

X-RAY DIFFRACTION (2.26 Å)