5VU0
Crystal structure of the complex between afucosylated/galactosylated human IgG1 Fc and Fc gamma receptor IIIa (CD16A) with Man5 N-glycans
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Immunoglobulin gamma-1 heavy chain | polymer | 217 | 24512.7 | 2 | UniProt (P0DOX5) Pfam (PF07654) In PDB | Homo sapiens (Human) | Immunoglobulin gamma-1 heavy chain NIE |
2 | C | Low affinity immunoglobulin gamma Fc region receptor III-A | polymer | 172 | 19727.1 | 1 | UniProt (H0Y755) Pfam (PF13895) UniProt (by SIFTS) (P08637) In PDB | Homo sapiens (Human) | |
3 | D, E | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1479.3 | 2 | In PDB GlyTouCan (G89993FE) | |||
4 | A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
5 | A, B | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
6 | A, B | SODIUM ION | non-polymer | 23.0 | 9 | Chemie (NA) | |||
7 | C | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
8 | water | water | 18.0 | 254 | Chemie (HOH) |
Sequence modifications
C: 3 - 174 (UniProt: H0Y755)
PDB | External Database | Details |
---|---|---|
Gln 38 | Asn 109 | engineered mutation |
Gln 74 | Asn 145 | engineered mutation |
Val 158 | Phe 229 | engineered mutation |
Gln 169 | Asn 240 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 68752.5 | |
Branched | Number of molecules | 2 |
Total formula weight | 2958.7 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 1384.1 | |
All* | Total formula weight | 73095.4 |