5VT3

High resolution structure of thioredoxin-disulfide reductase from Vibrio vulnificus CMCP6 in complex with NADP and FAD

Summary for 5VT3

• Entry DOI: 10.2210/pdb5vt3/pdb
• Descriptor: Thioredoxin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, ... (7 entities in total)
• Functional Keywords: structural genomics, center for structural genomics of infectious diseases, csgid, thioredoxin-disulfide reductase, oxidoreductase
• Biological source: Vibrio vulnificus CMCP6
• Total number of polymer chains: 2
• Total formula weight: 72904.11

Authors

Chang, C.,Grimshaw, S.,Maltseva, N.,Mulligan, R.,Anderson, W.F.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2017-05-15, release date: 2017-05-31, Last modification date: 2026-03-25)

Primary citation

Inniss, N.L.,Minasov, G.,Chang, C.,Tan, K.,Kim, Y.,Maltseva, N.,Stogios, P.,Filippova, E.,Michalska, K.,Osipiuk, J.,Jaroszewki, L.,Godzik, A.,Savchenko, A.,Joachimiak, A.,Anderson, W.F.,Satchell, K.J.F.
Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.
Microbiol Resour Announc, 14:e0020025-e0020025, 2025

PubMed Abstract: Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

PubMed: 40391899
DOI: 10.1128/mra.00200-25

Experimental method

X-RAY DIFFRACTION (1.98 Å)