Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019430 | biological_process | removal of superoxide radicals |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019430 | biological_process | removal of superoxide radicals |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 37 |
| Details | binding site for residue NAP A 401 |
| Chain | Residue |
| A | ASN52 |
| A | ARG178 |
| A | ARG182 |
| A | GLU184 |
| A | ILE243 |
| A | GLY244 |
| A | HIS245 |
| A | TYR292 |
| A | ARG293 |
| A | GLN294 |
| A | FAD402 |
| A | LEU120 |
| A | HOH513 |
| A | HOH515 |
| A | HOH516 |
| A | HOH520 |
| A | HOH527 |
| A | HOH538 |
| A | HOH543 |
| A | HOH557 |
| A | HOH560 |
| A | HOH582 |
| A | GLY154 |
| A | HOH588 |
| A | HOH614 |
| A | HOH616 |
| A | HOH618 |
| A | HOH647 |
| B | GLN196 |
| B | ASN197 |
| B | HOH625 |
| A | GLY155 |
| A | ASN156 |
| A | THR157 |
| A | GLU160 |
| A | HIS176 |
| A | ARG177 |
| site_id | AC2 |
| Number of Residues | 38 |
| Details | binding site for residue FAD A 402 |
| Chain | Residue |
| A | GLY13 |
| A | SER14 |
| A | GLY15 |
| A | PRO16 |
| A | ALA17 |
| A | THR36 |
| A | GLY37 |
| A | MET38 |
| A | GLN39 |
| A | GLY42 |
| A | GLN43 |
| A | LEU44 |
| A | THR47 |
| A | ASN52 |
| A | HIS84 |
| A | ILE85 |
| A | SER112 |
| A | THR113 |
| A | GLY114 |
| A | GLU160 |
| A | HIS245 |
| A | GLY285 |
| A | ASP286 |
| A | ARG293 |
| A | GLN294 |
| A | ALA295 |
| A | SER298 |
| A | NAP401 |
| A | K403 |
| A | HOH513 |
| A | HOH519 |
| A | HOH528 |
| A | HOH539 |
| A | HOH569 |
| A | HOH578 |
| A | HOH607 |
| A | HOH633 |
| B | TYR24 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue K A 403 |
| Chain | Residue |
| A | THR47 |
| A | GLU49 |
| A | GLU160 |
| A | FAD402 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CAC A 404 |
| Chain | Residue |
| A | ASP257 |
| A | THR276 |
| A | SER277 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 405 |
| Chain | Residue |
| A | GLY268 |
| A | HOH608 |
| B | SER267 |
| B | GOL401 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 401 |
| Chain | Residue |
| A | SER267 |
| A | GOL405 |
| B | SER267 |
| B | GLY268 |
| B | HOH566 |
| site_id | AC7 |
| Number of Residues | 32 |
| Details | binding site for residue NAP B 402 |
| Chain | Residue |
| B | ARG177 |
| B | ARG178 |
| B | ARG182 |
| B | ILE243 |
| B | GLY244 |
| B | HIS245 |
| B | TYR292 |
| B | ARG293 |
| B | GLN294 |
| B | FAD403 |
| B | HOH512 |
| B | HOH522 |
| B | HOH523 |
| B | HOH526 |
| B | HOH528 |
| B | HOH533 |
| B | HOH536 |
| B | HOH537 |
| B | HOH539 |
| B | HOH575 |
| B | HOH595 |
| B | HOH611 |
| B | HOH652 |
| B | HOH660 |
| B | ASN52 |
| B | LEU120 |
| B | GLY154 |
| B | GLY155 |
| B | ASN156 |
| B | THR157 |
| B | GLU160 |
| B | HIS176 |
| site_id | AC8 |
| Number of Residues | 37 |
| Details | binding site for residue FAD B 403 |
| Chain | Residue |
| A | TYR24 |
| B | GLY13 |
| B | SER14 |
| B | GLY15 |
| B | PRO16 |
| B | ALA17 |
| B | THR36 |
| B | GLY37 |
| B | MET38 |
| B | GLN39 |
| B | GLY42 |
| B | GLN43 |
| B | LEU44 |
| B | THR47 |
| B | ASN52 |
| B | HIS84 |
| B | ILE85 |
| B | SER112 |
| B | THR113 |
| B | GLY114 |
| B | ALA115 |
| B | GLU160 |
| B | HIS245 |
| B | GLY285 |
| B | ASP286 |
| B | ARG293 |
| B | GLN294 |
| B | ALA295 |
| B | SER298 |
| B | NAP402 |
| B | K404 |
| B | HOH516 |
| B | HOH517 |
| B | HOH559 |
| B | HOH569 |
| B | HOH585 |
| B | HOH598 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue K B 404 |
| Chain | Residue |
| B | THR47 |
| B | GLU49 |
| B | GLU160 |
| B | FAD403 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue CAC B 405 |
| Chain | Residue |
| B | LEU264 |
| B | LYS266 |
| B | SER277 |
Functional Information from PROSITE/UniProt
| site_id | PS00573 |
| Number of Residues | 21 |
| Details | PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CatCDGff..YrnqkVaVVGGGN |
| Chain | Residue | Details |
| A | CYS136-ASN156 | |
