5VND
Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to H3B-6527
Summary for 5VND
Entry DOI | 10.2210/pdb5vnd/pdb |
Descriptor | Fibroblast growth factor receptor 1, N-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-5-(4-ethylpiperazin-1-yl)phenyl}propanamide, SULFATE ION, ... (5 entities in total) |
Functional Keywords | fgfr4, h3b-56527, covalent compound, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 72729.00 |
Authors | Tsai, J.H.C.,Reynolds, D.,Fekkes, P.,Smith, P.,Larsen, N.A. (deposition date: 2017-04-30, release date: 2017-05-24, Last modification date: 2023-10-04) |
Primary citation | Joshi, J.J.,Coffey, H.,Corcoran, E.,Tsai, J.,Huang, C.L.,Ichikawa, K.,Prajapati, S.,Hao, M.H.,Bailey, S.,Wu, J.,Rimkunas, V.,Karr, C.,Subramanian, V.,Kumar, P.,MacKenzie, C.,Hurley, R.,Satoh, T.,Yu, K.,Park, E.,Rioux, N.,Kim, A.,Lai, W.G.,Yu, L.,Zhu, P.,Buonamici, S.,Larsen, N.,Fekkes, P.,Wang, J.,Warmuth, M.,Reynolds, D.J.,Smith, P.G.,Selvaraj, A. H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma. Cancer Res., 77:6999-7013, 2017 Cited by PubMed: 29247039DOI: 10.1158/0008-5472.CAN-17-1865 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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