5VND

Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to H3B-6527

5VND の概要

• エントリーDOI: 10.2210/pdb5vnd/pdb
• 分子名称: Fibroblast growth factor receptor 1, N-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-5-(4-ethylpiperazin-1-yl)phenyl}propanamide, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: fgfr4, h3b-56527, covalent compound, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72729.00

構造登録者

Tsai, J.H.C.,Reynolds, D.,Fekkes, P.,Smith, P.,Larsen, N.A. (登録日: 2017-04-30, 公開日: 2017-05-24, 最終更新日: 2023-10-04)

• 主引用文献: Joshi, J.J.,Coffey, H.,Corcoran, E.,Tsai, J.,Huang, C.L.,Ichikawa, K.,Prajapati, S.,Hao, M.H.,Bailey, S.,Wu, J.,Rimkunas, V.,Karr, C.,Subramanian, V.,Kumar, P.,MacKenzie, C.,Hurley, R.,Satoh, T.,Yu, K.,Park, E.,Rioux, N.,Kim, A.,Lai, W.G.,Yu, L.,Zhu, P.,Buonamici, S.,Larsen, N.,Fekkes, P.,Wang, J.,Warmuth, M.,Reynolds, D.J.,Smith, P.G.,Selvaraj, A.; H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma.; Cancer Res., 77:6999-7013, 2017; PubMed: 29247039; DOI: 10.1158/0008-5472.CAN-17-1865

実験手法

X-RAY DIFFRACTION (2.2 Å)