5VLH

Short PCSK9 delta-P' complex with peptide Pep1

Summary for 5VLH

• Entry DOI: 10.2210/pdb5vlh/pdb
• Related: 5VL7 5VLA 5VLK 5VLL 5VLP
• Descriptor: Proprotein convertase subtilisin/kexin type 9, CYS-ARG-LEU-PRO-TRP-ASN-LEU-GLN-ARG-ILE-GLY-LEU-PRO-CYS, ACE-THR-VAL-PHE-THR-SER-TRP-GLU-GLU-TYR-LEU-ASP-TRP-VAL-NH2, ... (4 entities in total)
• Functional Keywords: proprotein convertase, subtilisin, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 53194.10

Authors

Eigenbrot, C.,Ultsch, M. (deposition date: 2017-04-25, release date: 2017-08-16, Last modification date: 2023-10-04)

• Primary citation: Zhang, Y.,Ultsch, M.,Skelton, N.J.,Burdick, D.J.,Beresini, M.H.,Li, W.,Kong-Beltran, M.,Peterson, A.,Quinn, J.,Chiu, C.,Wu, Y.,Shia, S.,Moran, P.,Di Lello, P.,Eigenbrot, C.,Kirchhofer, D.; Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists.; Nat. Struct. Mol. Biol., 24:848-856, 2017; PubMed: 28825733; DOI: 10.1038/nsmb.3453

Experimental method

X-RAY DIFFRACTION (2.86 Å)