5VK1

Crystal structure of human MDM4 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI

Summary for 5VK1

• Entry DOI: 10.2210/pdb5vk1/pdb
• Related: 3eqy 5VK0
• Descriptor: Protein Mdm4, Lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI (3 entities in total)
• Functional Keywords: mdmx, mdmx-peptide inhibitor complex, oncoprotein, metal-binding, nucleus, zinc-finger, stapled peptide, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 16
• Total formula weight: 88952.97

Authors

Tolbert, W.D.,Gohain, N.,Pazgier, M. (deposition date: 2017-04-20, release date: 2018-04-25, Last modification date: 2023-10-04)

• Primary citation: Li, X.,Tolbert, W.D.,Hu, H.G.,Gohain, N.,Zou, Y.,Niu, F.,He, W.X.,Yuan, W.,Su, J.C.,Pazgier, M.,Lu, W.; Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design.; Chem Sci, 10:1522-1530, 2019; PubMed: 30809370; DOI: 10.1039/c8sc03275k

Experimental method

X-RAY DIFFRACTION (2.69 Å)