5VK1
Crystal structure of human MDM4 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G, I... (A, C, E, G, I...) | Protein Mdm4 | polymer | 85 | 9575.3 | 8 | UniProt (O15151) | Homo sapiens | Double minute 4 protein,Mdm2-like p53-binding protein,Protein Mdmx,p53-binding protein Mdm4 |
| 2 | B, D, F, H, J... (B, D, F, H, J...) | Lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI | polymer | 14 | 1543.8 | 8 | synthetic construct | ||
| 3 | Q, R, S, T, U... (A, B, C, E, G...) | water | water | 18.0 | 27 | Chemie (HOH) |
Sequence modifications
A, C, E, G, I, K, M, O: 24 - 108 (UniProt: O15151)
| PDB | External Database | Details |
|---|---|---|
| Ala 68 | Gln 68 | engineered mutation |
| Ala 69 | Gln 69 | engineered mutation |
| Ala 70 | Glu 70 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 16 |
| Total formula weight | 88953.0 | |
| All* | Total formula weight | 88953.0 |
