5VJA

Crystal Structure of human zipper-interacting protein kinase (ZIPK, alias DAPK3) in complex with a pyrazolo[3,4-d]pyrimidinone ligand (HS38)

Summary for 5VJA

Entry DOI	10.2210/pdb5vja/pdb
Descriptor	Death-associated protein kinase 3, DIMETHYL SULFOXIDE, (2R)-2-{[1-(3-chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl}propanamide, ... (5 entities in total)
Functional Keywords	death-associated protein kinase 3, transferase, inhibitor, smooth muscle contraction, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	132023.38
Authors	Carlson, D.A.,Singer, M.R.,Sutherland, C.,Redondo, C.,Alexander, L.,Hughes, P.F.,Knapp, S.,MacDonald, J.A.,Haystead, T.A.J. (deposition date: 2017-04-19, release date: 2018-08-08, Last modification date: 2023-10-04)
Primary citation	Carlson, D.A.,Singer, M.R.,Sutherland, C.,Redondo, C.,Alexander, L.T.,Hughes, P.F.,Knapp, S.,Gurley, S.B.,Sparks, M.A.,MacDonald, J.A.,Haystead, T.A.J. Targeting Pim Kinases and DAPK3 to Control Hypertension. Cell Chem Biol, 25:1195-, 2018 Cited by PubMed: 30033129 DOI: 10.1016/j.chembiol.2018.06.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.46 Å)

Structure validation