5VJA
Crystal Structure of human zipper-interacting protein kinase (ZIPK, alias DAPK3) in complex with a pyrazolo[3,4-d]pyrimidinone ligand (HS38)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Death-associated protein kinase 3 | polymer | 283 | 32545.1 | 4 | UniProt (O43293) Pfam (PF00069) | Homo sapiens (Human) | DAP kinase 3,DAP-like kinase,Dlk,MYPT1 kinase,Zipper-interacting protein kinase,ZIP-kinase |
| 2 | E, G, I, L (A, B, C, D) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
| 3 | F, H, J, M (A, B, C, D) | (2R)-2-{[1-(3-chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl]sulfanyl}propanamide | non-polymer | 349.8 | 4 | Chemie (DUK) | |||
| 4 | K (D) | ISOLEUCINE | non-polymer | 131.2 | 1 | Chemie (ILE) | |||
| 5 | N, O, P, Q (A, B, C, D) | water | water | 18.0 | 476 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 9 - 289 (UniProt: O43293)
| PDB | External Database | Details |
|---|---|---|
| Ser 7 | - | expression tag |
| Met 8 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 130180.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1842.9 | |
| All* | Total formula weight | 132023.4 |
