5VI6
Crystal structure of histone deacetylase 8 in complex with trapoxin A
Summary for 5VI6
Entry DOI | 10.2210/pdb5vi6/pdb |
Related PRD ID | PRD_002282 |
Descriptor | Histone deacetylase 8, Trapoxin A, ZINC ION, ... (7 entities in total) |
Functional Keywords | hdac, epigenetics, natural product inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 42741.02 |
Authors | Porter, N.J.,Christianson, D.W. (deposition date: 2017-04-14, release date: 2017-09-06, Last modification date: 2023-11-15) |
Primary citation | Porter, N.J.,Christianson, D.W. Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8. ACS Chem. Biol., 12:2281-2286, 2017 Cited by PubMed: 28846375DOI: 10.1021/acschembio.7b00330 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.237 Å) |
Structure validation
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