5VH4

Crystal structure of Fab fragment of anti-TNFa antibody infliximab in an I-centered orthorhombic crystal form

Summary for 5VH4

• Entry DOI: 10.2210/pdb5vh4/pdb
• Related: 5VH3 5VH5
• Descriptor: Infliximab Fab Heavy Chain, Infliximab Fab Light Chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (5 entities in total)
• Functional Keywords: antibody, fab, biosimilar, infliximab, tnfa, anti-tnfa, immune system
• Biological source: Mus musculus, Homo sapiens; More
• Total number of polymer chains: 4
• Total formula weight: 97271.29

Authors

Mayclin, S.J.,Edwards, T.E.,Lerch, T.F.,Conlan, H.,Sharpe, P. (deposition date: 2017-04-12, release date: 2017-05-03, Last modification date: 2023-10-04)

• Primary citation: Lerch, T.F.,Sharpe, P.,Mayclin, S.J.,Edwards, T.E.,Lee, E.,Conlon, H.D.,Polleck, S.,Rouse, J.C.,Luo, Y.,Zou, Q.; Infliximab crystal structures reveal insights into self-association.; MAbs, 9:874-883, 2017; PubMed: 28421849; DOI: 10.1080/19420862.2017.1320463

Experimental method

X-RAY DIFFRACTION (2 Å)