Crystal Structure of Human Glycine Receptor alpha-3 Bound to AM-3607, Glycine, and Ivermectin

Summary for 5VDH

DescriptorGlycine receptor subunit alpha-3, (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one, GLYCINE, ... (8 entities in total)
Functional Keywordsligand-gated ion channel, neurotransmitter receptor, membrane protein, cys-loop receptor, transport protein
Biological sourceHomo sapiens (Human)
Cellular locationCell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein  O75311
Total number of polymer chains5
Total molecular weight216628.7
Shaffer, P.L.,Huang, X.,Chen, H. (deposition date: 2017-04-03, release date: 2017-05-24, Last modification date: 2017-06-21)
Primary citation
Huang, X.,Chen, H.,Shaffer, P.L.
Crystal Structures of Human GlyR alpha 3 Bound to Ivermectin.
Structure, 25:945-950.e2, 2017
PubMed: 28479061 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2017.04.007
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.229102.1%6.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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