5VDA

Crystal structure of human WEE1 kinase domain in complex with RAC-IV-101, a MK1775 analogue

Summary for 5VDA

• Entry DOI: 10.2210/pdb5vda/pdb
• Related: 5VC3 5VC4 5VC5 5VC6 5VD2 5VD4 5VD5 5VD7 5VD8
• Descriptor: Wee1-like protein kinase, 1-{6-[(1S)-1-hydroxyethyl]pyridin-2-yl}-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: kinase domain, cell cycle, wee1, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 33024.99

Authors

Zhu, J.-Y.,Schonbrunn, E. (deposition date: 2017-04-01, release date: 2018-04-04, Last modification date: 2024-03-06)

• Primary citation: Zhu, J.-Y.,Schonbrunn, E.; Structural basis of Wee family kinase inhibition by small molecules; to be published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)