5VB6

X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with an inverse agonist and SRC2 peptide

Summary for 5VB6

Entry DOI	10.2210/pdb5vb6/pdb
Related	5VB3 5VB5 5VB7
Descriptor	Nuclear receptor ROR-gamma, SRC2 chimera, SODIUM ION, N-{3-[(3-methylbut-2-en-1-yl){methyl[trans-4-(pyridin-4-yl)cyclohexyl]carbamoyl}amino]phenyl}benzamide, ... (4 entities in total)
Functional Keywords	nuclear receptor, nuclear hormone receptor, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	32962.07
Authors	Li, X. (deposition date: 2017-03-28, release date: 2017-06-07, Last modification date: 2024-03-06)
Primary citation	Li, X.,Anderson, M.,Collin, D.,Muegge, I.,Wan, J.,Brennan, D.,Kugler, S.,Terenzio, D.,Kennedy, C.,Lin, S.,Labadia, M.E.,Cook, B.,Hughes, R.,Farrow, N.A. Structural studies unravel the active conformation of apo ROR gamma t nuclear receptor and a common inverse agonism of two diverse classes of ROR gamma t inhibitors. J. Biol. Chem., 292:11618-11630, 2017 Cited by PubMed: 28546429 DOI: 10.1074/jbc.M117.789024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.041 Å)

Structure validation