5V7T

crystal structure of PARP14 bound to N-{4-[4-(diphenylmethoxy)piperidin-1-yl]butyl}[1,2,4]triazolo[4,3-b]pyridazin-6-amine inhibitor

Summary for 5V7T

• Entry DOI: 10.2210/pdb5v7t/pdb
• Related: 5V7W
• Descriptor: Poly [ADP-ribose] polymerase 14, N-{4-[4-(diphenylmethoxy)piperidin-1-yl]butyl}[1,2,4]triazolo[4,3-b]pyridazin-6-amine (3 entities in total)
• Functional Keywords: human parp14, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus: Q460N5
• Total number of polymer chains: 1
• Total formula weight: 22558.08

Authors

saikatendu, k.s.,Hirozane, M. (deposition date: 2017-03-20, release date: 2017-05-03)

• Primary citation: Yoneyama-Hirozane, M.,Matsumoto, S.I.,Toyoda, Y.,Saikatendu, K.S.,Zama, Y.,Yonemori, K.,Oonishi, M.,Ishii, T.,Kawamoto, T.; Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation.; Biochem. Biophys. Res. Commun., 486:626-631, 2017; PubMed: 28315326; DOI: 10.1016/j.bbrc.2017.03.052

Experimental method

X-RAY DIFFRACTION (2.3 Å)