5V7T
crystal structure of PARP14 bound to N-{4-[4-(diphenylmethoxy)piperidin-1-yl]butyl}[1,2,4]triazolo[4,3-b]pyridazin-6-amine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Poly [ADP-ribose] polymerase 14 | polymer | 194 | 22101.5 | 1 | UniProt (Q460N5) Pfam (PF00644) | Homo sapiens (Human) | PARP-14,ADP-ribosyltransferase diphtheria toxin-like 8,ARTD8,B aggressive lymphoma protein 2 |
| 2 | B (A) | N-{4-[4-(diphenylmethoxy)piperidin-1-yl]butyl}[1,2,4]triazolo[4,3-b]pyridazin-6-amine | non-polymer | 456.6 | 1 | Chemie (91V) | |||
| 3 | C (A) | water | water | 18.0 | 67 | Chemie (HOH) |
Sequence modifications
A: 1529 - 1720 (UniProt: Q460N5)
| PDB | External Database | Details |
|---|---|---|
| Gly 1527 | - | expression tag |
| Gly 1528 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 22101.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 456.6 | |
| All* | Total formula weight | 22558.1 |
