5V6Y

Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity and altered selectivity adrenomedullin variant

Summary for 5V6Y

• Entry DOI: 10.2210/pdb5v6y/pdb
• Related: 4RWG
• Related PRD ID: PRD_900001
• Descriptor: Maltose-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor, ADM, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: class b g protein-coupled receptor, gpcr, calcitonin family peptide, transport protein - membrane protein complex, transport protein / membrane protein
• Biological source: Escherichia coli O157:H7; More
• Total number of polymer chains: 8
• Total formula weight: 274192.04

Authors

Pioszak, A.,Booe, J. (deposition date: 2017-03-17, release date: 2018-01-31, Last modification date: 2023-10-04)

• Primary citation: Booe, J.M.,Warner, M.L.,Roehrkasse, A.M.,Hay, D.L.,Pioszak, A.A.; Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists.; Mol. Pharmacol., 93:355-367, 2018; PubMed: 29363552; DOI: 10.1124/mol.117.110916

Experimental method

X-RAY DIFFRACTION (2.8 Å)