5V6Y

Crystal structure of the human CLR:RAMP1 extracellular domain heterodimer with bound high-affinity and altered selectivity adrenomedullin variant

5V6Y の概要

• エントリーDOI: 10.2210/pdb5v6y/pdb
• 関連するPDBエントリー: 4RWG
• 関連するBIRD辞書のPRD_ID: PRD_900001
• 分子名称: Maltose-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor, ADM, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: class b g protein-coupled receptor, gpcr, calcitonin family peptide, transport protein - membrane protein complex, transport protein / membrane protein
• 由来する生物種: Escherichia coli O157:H7; 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 274192.04

構造登録者

Pioszak, A.,Booe, J. (登録日: 2017-03-17, 公開日: 2018-01-31, 最終更新日: 2023-10-04)

• 主引用文献: Booe, J.M.,Warner, M.L.,Roehrkasse, A.M.,Hay, D.L.,Pioszak, A.A.; Probing the Mechanism of Receptor Activity-Modifying Protein Modulation of GPCR Ligand Selectivity through Rational Design of Potent Adrenomedullin and Calcitonin Gene-Related Peptide Antagonists.; Mol. Pharmacol., 93:355-367, 2018; PubMed: 29363552; DOI: 10.1124/mol.117.110916

実験手法

X-RAY DIFFRACTION (2.8 Å)