5V59
Crystal structure of catalytic fragment of human AlaRS in complex with Aze-SA
Summary for 5V59
Entry DOI | 10.2210/pdb5v59/pdb |
Related | 5V58 |
Descriptor | Alanine--tRNA ligase, cytoplasmic, 5'-O-{[(2S)-azetidine-2-carbonyl]sulfamoyl}adenosine (3 entities in total) |
Functional Keywords | ligase, aminoacyl-trna synthetase, non-proteinogenic amino acid |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 53743.60 |
Authors | Zhou, H.,Song, Y.,Schimmel, P. (deposition date: 2017-03-13, release date: 2018-01-10, Last modification date: 2023-10-04) |
Primary citation | Song, Y.,Zhou, H.,Vo, M.N.,Shi, Y.,Nawaz, M.H.,Vargas-Rodriguez, O.,Diedrich, J.K.,Yates, J.R.,Kishi, S.,Musier-Forsyth, K.,Schimmel, P. Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid. Nat Commun, 8:2281-2281, 2017 Cited by PubMed: 29273753DOI: 10.1038/s41467-017-02201-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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