5V54
Crystal structure of 5-HT1B receptor in complex with methiothepin
Summary for 5V54
Entry DOI | 10.2210/pdb5v54/pdb |
Descriptor | 5-hydroxytryptamine receptor 1B,OB-1 fused 5-HT1b receptor,5-hydroxytryptamine receptor 1B, 1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine (2 entities in total) |
Functional Keywords | 5-hydroxytryptamine, gpcr antagonist, ob1, electron transport |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Multi-pass membrane protein : P28222 |
Total number of polymer chains | 2 |
Total formula weight | 90643.41 |
Authors | Yin, W.C.,Zhou, X.E.,Yang, D.,de Waal, P.,Wang, M.T.,Dai, A.,Cai, X.,Huang, C.Y.,Liu, P.,Yin, Y.,Liu, B.,Caffrey, M.,Melcher, K.,Xu, Y.,Wang, M.W.,Xu, H.E.,Jiang, Y. (deposition date: 2017-03-13, release date: 2018-02-07) |
Primary citation | Yin, W.C.,Zhou, X.E.,Yang, D.,De Waal, P.,Wang, M.T.,Dai, A.,Cai, X.,Huang, C.Y.,Liu, P.,Yin, Y.,Liu, B.,Caffrey, M.,Melcher, K.,Xu, Y.,Wang, M.W.,Xu, H.E.,Jiang, Y. A common antagonistic mechanism for class A GPCRs revealed by the structure of the human 5-HT1B serotonin receptor bound to an antagonist Cell Discov, 2018 |
Experimental method | X-RAY DIFFRACTION (3.9 Å) |
Structure validation
Download full validation report