5V54

Crystal structure of 5-HT1B receptor in complex with methiothepin

5V54 の概要

• エントリーDOI: 10.2210/pdb5v54/pdb
• 分子名称: 5-hydroxytryptamine receptor 1B,OB-1 fused 5-HT1b receptor,5-hydroxytryptamine receptor 1B, 1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine (2 entities in total)
• 機能のキーワード: 5-hydroxytryptamine, gpcr antagonist, ob1, electron transport
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane ; Multi-pass membrane protein : P28222
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 90643.41

構造登録者

Yin, W.C.,Zhou, X.E.,Yang, D.,de Waal, P.,Wang, M.T.,Dai, A.,Cai, X.,Huang, C.Y.,Liu, P.,Yin, Y.,Liu, B.,Caffrey, M.,Melcher, K.,Xu, Y.,Wang, M.W.,Xu, H.E.,Jiang, Y. (登録日: 2017-03-13, 公開日: 2018-02-07)

• 主引用文献: Yin, W.C.,Zhou, X.E.,Yang, D.,De Waal, P.,Wang, M.T.,Dai, A.,Cai, X.,Huang, C.Y.,Liu, P.,Yin, Y.,Liu, B.,Caffrey, M.,Melcher, K.,Xu, Y.,Wang, M.W.,Xu, H.E.,Jiang, Y.; A common antagonistic mechanism for class A GPCRs revealed by the structure of the human 5-HT1B serotonin receptor bound to an antagonist; Cell Discov, 2018

実験手法

X-RAY DIFFRACTION (3.9 Å)