5UXB

Crystal structure of macrolide 2'-phosphotransferase MphH from Brachybacterium faecium, apoenzyme

5UXB の概要

• エントリーDOI: 10.2210/pdb5uxb/pdb
• 関連するPDBエントリー: 5UXA 5UXC 5UXD
• 分子名称: Macrolide 2'-phosphotransferase MphH, CHLORIDE ION (3 entities in total)
• 機能のキーワード: antibiotic resistance, macrolide, cave bacterium, phosphotransferase, kinase, alpha/beta protein, azithromycin, structural genomics, center for structural genomics of infectious diseases, csgid, national institute of allergy and infectious diseases, niaid, transferase
• 由来する生物種: Brachybacterium faecium (strain ATCC 43885 / DSM 4810 / NCIB 9860)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 64606.64

構造登録者

Stogios, P.J.,Skarina, T.,Yim, V.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2017-02-22, 公開日: 2017-07-26, 最終更新日: 2023-11-15)

• 主引用文献: Pawlowski, A.C.,Stogios, P.J.,Koteva, K.,Skarina, T.,Evdokimova, E.,Savchenko, A.,Wright, G.D.; The evolution of substrate discrimination in macrolide antibiotic resistance enzymes.; Nat Commun, 9:112-112, 2018; PubMed: 29317655; DOI: 10.1038/s41467-017-02680-0

実験手法

X-RAY DIFFRACTION (2.794 Å)