5UXA

Crystal structure of macrolide 2'-phosphotransferase MphB from Escherichia coli

Summary for 5UXA

• Entry DOI: 10.2210/pdb5uxa/pdb
• Related: 5UXB 5UXC 5UXD
• Descriptor: Macrolide 2'-phosphotransferase II, CALCIUM ION (3 entities in total)
• Functional Keywords: antibiotic resistance, macrolide, phosphotransferase, kinase, structural genomics, center for structural genomics of infectious diseases, csgid, national institute of allergy and infectious diseases, niaid, transferase
• Biological source: Escherichia coli
• Total number of polymer chains: 1
• Total formula weight: 34647.44

Authors

Stogios, P.J.,Evdokimova, E.,Egorova, O.,Di Leo, R.,Yim, V.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2017-02-22, release date: 2017-06-28, Last modification date: 2024-03-06)

• Primary citation: Pawlowski, A.C.,Stogios, P.J.,Koteva, K.,Skarina, T.,Evdokimova, E.,Savchenko, A.,Wright, G.D.; The evolution of substrate discrimination in macrolide antibiotic resistance enzymes.; Nat Commun, 9:112-112, 2018; PubMed: 29317655; DOI: 10.1038/s41467-017-02680-0

Experimental method

X-RAY DIFFRACTION (1.95 Å)