Summary for 5UU1
| Entry DOI | 10.2210/pdb5uu1/pdb |
| Descriptor | Serine/threonine-protein kinase VRK2, (7S)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one (3 entities in total) |
| Functional Keywords | transferase, protein kinase domain, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 37179.65 |
| Authors | Counago, R.M.,Bountra, C.,Arruda, P.,Edwards, A.M.,Gileadi, O.,Structural Genomics Consortium (SGC) (deposition date: 2017-02-15, release date: 2017-03-01, Last modification date: 2023-10-04) |
| Primary citation | Counago, R.M.,Allerston, C.K.,Savitsky, P.,Azevedo, H.,Godoi, P.H.,Wells, C.I.,Mascarello, A.,de Souza Gama, F.H.,Massirer, K.B.,Zuercher, W.J.,Guimaraes, C.R.W.,Gileadi, O. Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations. Sci Rep, 7:7501-7501, 2017 Cited by PubMed: 28790404DOI: 10.1038/s41598-017-07755-y PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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