5USQ
ALK-5 kinase inhibitor complex
Summary for 5USQ
Entry DOI | 10.2210/pdb5usq/pdb |
Descriptor | TGF-beta receptor type-1, N-[2-(5-chloro-2-fluorophenyl)pyridin-4-yl]-2-[(piperidin-4-yl)methyl]-2H-pyrazolo[4,3-b]pyridin-7-amine (3 entities in total) |
Functional Keywords | tgf-beta receptor type i, serine/threonine-protein kinase receptor r4, activin receptor-like kinase 5, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P36897 |
Total number of polymer chains | 1 |
Total formula weight | 34702.31 |
Authors | Dougan, D.R.,Lawson, J.D. (deposition date: 2017-02-13, release date: 2017-04-12, Last modification date: 2024-03-06) |
Primary citation | Sabat, M.,Wang, H.,Scorah, N.,Lawson, J.D.,Atienza, J.,Kamran, R.,Hixon, M.S.,Dougan, D.R. Design, synthesis and optimization of 7-substituted-pyrazolo[4,3-b]pyridine ALK5 (activin receptor-like kinase 5) inhibitors. Bioorg. Med. Chem. Lett., 27:1955-1961, 2017 Cited by PubMed: 28359790DOI: 10.1016/j.bmcl.2017.03.026 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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