6U60

Crystal structure of prephenate dehydrogenase tyrA from Bacillus anthracis in complex with NAD and L-tyrosine

Replaces:  5USC

Summary for 6U60

• Entry DOI: 10.2210/pdb6u60/pdb
• Descriptor: Prephenate dehydrogenase, TYROSINE, PHOSPHATE ION, ... (5 entities in total)
• Functional Keywords: structural genomics, center for structural genomics of infectious diseases, csgid, hydrolase
• Biological source: Bacillus anthracis
• Total number of polymer chains: 2
• Total formula weight: 86631.29

Authors

Shabalin, I.G.,Hou, J.,Kutner, J.,Grimshaw, S.,Christendat, D.,Anderson, W.F.,Minor, W.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2019-08-28, release date: 2019-09-11, Last modification date: 2023-10-11)

• Primary citation: Shabalin, I.G.,Gritsunov, A.,Hou, J.,Slawek, J.,Miks, C.D.,Cooper, D.R.,Minor, W.,Christendat, D.; Structural and biochemical analysis of Bacillus anthracis prephenate dehydrogenase reveals an unusual mode of inhibition by tyrosine via the ACT domain.; Febs J., 287:2235-2255, 2020; PubMed: 31750992; DOI: 10.1111/febs.15150

Experimental method

X-RAY DIFFRACTION (2.1 Å)