6U60
Crystal structure of prephenate dehydrogenase tyrA from Bacillus anthracis in complex with NAD and L-tyrosine
Replaces: 5USCFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004665 | molecular_function | prephenate dehydrogenase (NADP+) activity |
| A | 0006571 | biological_process | L-tyrosine biosynthetic process |
| A | 0008977 | molecular_function | prephenate dehydrogenase (NAD+) activity |
| A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004665 | molecular_function | prephenate dehydrogenase (NADP+) activity |
| B | 0006571 | biological_process | L-tyrosine biosynthetic process |
| B | 0008977 | molecular_function | prephenate dehydrogenase (NAD+) activity |
| B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue TYR A 401 |
| Chain | Residue |
| A | ASN152 |
| B | LEU320 |
| B | VAL349 |
| A | SER333 |
| A | ILE334 |
| A | HOH515 |
| A | HOH526 |
| A | HOH530 |
| B | ASP315 |
| B | LYS316 |
| B | ALA319 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue TYR A 402 |
| Chain | Residue |
| A | VAL313 |
| A | LEU314 |
| A | ASP315 |
| A | LYS316 |
| A | ALA319 |
| A | LEU320 |
| A | ILE339 |
| A | GLU341 |
| A | GLY348 |
| A | HOH539 |
| A | HOH553 |
| B | LYS139 |
| B | SER333 |
| B | ILE334 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 403 |
| Chain | Residue |
| A | ARG298 |
| A | HIS307 |
| A | GLU357 |
| A | ARG360 |
| site_id | AC4 |
| Number of Residues | 28 |
| Details | binding site for residue NAD B 1001 |
| Chain | Residue |
| B | GLY21 |
| B | GLY23 |
| B | LEU24 |
| B | ILE25 |
| B | ASP45 |
| B | ILE46 |
| B | PHE47 |
| B | ALA80 |
| B | PRO82 |
| B | GLU85 |
| B | VAL107 |
| B | GLY108 |
| B | SER109 |
| B | PRO133 |
| B | ALA135 |
| B | GLY136 |
| B | THR140 |
| B | GLY141 |
| B | HOH1129 |
| B | HOH1132 |
| B | HOH1144 |
| B | HOH1152 |
| B | HOH1176 |
| B | HOH1188 |
| B | HOH1189 |
| B | HOH1191 |
| B | HOH1207 |
| B | HOH1226 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 B 1002 |
| Chain | Residue |
| A | GLY228 |
| A | ASP232 |
| A | HOH564 |
| B | ARG298 |
| B | ARG360 |
| B | HOH1118 |
