6U60
Crystal structure of prephenate dehydrogenase tyrA from Bacillus anthracis in complex with NAD and L-tyrosine
Replaces: 5USCFunctional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0004665 | molecular_function | prephenate dehydrogenase (NADP+) activity |
A | 0006571 | biological_process | tyrosine biosynthetic process |
A | 0008977 | molecular_function | prephenate dehydrogenase (NAD+) activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0070403 | molecular_function | NAD+ binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0004665 | molecular_function | prephenate dehydrogenase (NADP+) activity |
B | 0006571 | biological_process | tyrosine biosynthetic process |
B | 0008977 | molecular_function | prephenate dehydrogenase (NAD+) activity |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0046872 | molecular_function | metal ion binding |
B | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 11 |
Details | binding site for residue TYR A 401 |
Chain | Residue |
A | ASN152 |
B | LEU320 |
B | VAL349 |
A | SER333 |
A | ILE334 |
A | HOH515 |
A | HOH526 |
A | HOH530 |
B | ASP315 |
B | LYS316 |
B | ALA319 |
site_id | AC2 |
Number of Residues | 14 |
Details | binding site for residue TYR A 402 |
Chain | Residue |
A | VAL313 |
A | LEU314 |
A | ASP315 |
A | LYS316 |
A | ALA319 |
A | LEU320 |
A | ILE339 |
A | GLU341 |
A | GLY348 |
A | HOH539 |
A | HOH553 |
B | LYS139 |
B | SER333 |
B | ILE334 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue PO4 A 403 |
Chain | Residue |
A | ARG298 |
A | HIS307 |
A | GLU357 |
A | ARG360 |
site_id | AC4 |
Number of Residues | 28 |
Details | binding site for residue NAD B 1001 |
Chain | Residue |
B | GLY21 |
B | GLY23 |
B | LEU24 |
B | ILE25 |
B | ASP45 |
B | ILE46 |
B | PHE47 |
B | ALA80 |
B | PRO82 |
B | GLU85 |
B | VAL107 |
B | GLY108 |
B | SER109 |
B | PRO133 |
B | ALA135 |
B | GLY136 |
B | THR140 |
B | GLY141 |
B | HOH1129 |
B | HOH1132 |
B | HOH1144 |
B | HOH1152 |
B | HOH1176 |
B | HOH1188 |
B | HOH1189 |
B | HOH1191 |
B | HOH1207 |
B | HOH1226 |
site_id | AC5 |
Number of Residues | 6 |
Details | binding site for residue PO4 B 1002 |
Chain | Residue |
A | GLY228 |
A | ASP232 |
A | HOH564 |
B | ARG298 |
B | ARG360 |
B | HOH1118 |