5UR7
Crystal structure of engineered CCL20 disulfide locked dimer
Summary for 5UR7
Entry DOI | 10.2210/pdb5ur7/pdb |
Descriptor | C-C motif chemokine 20, ACETATE ION, ISOPROPYL ALCOHOL, ... (4 entities in total) |
Functional Keywords | ccl20, chemokine, macrophage inflammatory protein-3 alpha, mip3-alpha, chemotaxis, psoriasis, locked dimer, cytokine, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 16474.58 |
Authors | Getschman, A.E.,Peterson, F.C.,Volkman, B.F. (deposition date: 2017-02-09, release date: 2017-11-22, Last modification date: 2023-10-04) |
Primary citation | Getschman, A.E.,Imai, Y.,Larsen, O.,Peterson, F.C.,Wu, X.,Rosenkilde, M.M.,Hwang, S.T.,Volkman, B.F. Protein engineering of the chemokine CCL20 prevents psoriasiform dermatitis in an IL-23-dependent murine model. Proc. Natl. Acad. Sci. U.S.A., 114:12460-12465, 2017 Cited by PubMed: 29109267DOI: 10.1073/pnas.1704958114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.0004 Å) |
Structure validation
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