5UQ9

Crystal structure of 6-phosphogluconate dehydrogenase with ((4R,5R)-5-(hydroxycarbamoyl)-2,2-dimethyl-1,3-dioxolan-4-yl)methyl dihydrogen phosphate

Summary for 5UQ9

• Entry DOI: 10.2210/pdb5uq9/pdb
• Related: 2JKV 4GWG 4GWK
• Descriptor: 6-phosphogluconate dehydrogenase, decarboxylating, [(4R,5R)-5-(hydroxycarbamoyl)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl dihydrogen phosphate (2 entities in total)
• Functional Keywords: rossmann fold, pentose phosphate pathway, dehydrogenase, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 8
• Total formula weight: 430379.19

Authors

Leonard, P.G. (deposition date: 2017-02-07, release date: 2018-08-22, Last modification date: 2023-10-04)

• Primary citation: Sun, Y.,Bandi, M.,Lofton, T.,Smith, M.,Bristow, C.A.,Carugo, A.,Rogers, N.,Leonard, P.,Chang, Q.,Mullinax, R.,Han, J.,Shi, X.,Seth, S.,Meyers, B.A.,Miller, M.,Miao, L.,Ma, X.,Feng, N.,Giuliani, V.,Geck Do, M.,Czako, B.,Palmer, W.S.,Mseeh, F.,Asara, J.M.,Jiang, Y.,Morlacchi, P.,Zhao, S.,Peoples, M.,Tieu, T.N.,Warmoes, M.O.,Lorenzi, P.L.,Muller, F.L.,DePinho, R.A.,Draetta, G.F.,Toniatti, C.,Jones, P.,Heffernan, T.P.,Marszalek, J.R.; Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation.; Cell Rep, 26:469-482.e5, 2019; PubMed: 30625329; DOI: 10.1016/j.celrep.2018.12.043

Experimental method

X-RAY DIFFRACTION (3 Å)