5UOS

Crystal Structure of CblC (MMACHC) (1-238), a human B12 processing enzyme, complexed with an Antivitamin B12

5UOS の概要

• エントリーDOI: 10.2210/pdb5uos/pdb
• 分子名称: Methylmalonic aciduria and homocystinuria type C protein, COBALAMIN, 1-ethynyl-2,4-difluorobenzene, ... (8 entities in total)
• 機能のキーワード: vitamin b12, oxidoreductase, b12 trafficking, b12 processing, b12 binding
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q9Y4U1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29681.66

構造登録者

Shanmuganathan, A.,Karasik, A.,Ruetz, M.,Banerjee, R.,Krautler, B.,Koutmos, M. (登録日: 2017-02-01, 公開日: 2017-06-07, 最終更新日: 2023-10-04)

• 主引用文献: Ruetz, M.,Shanmuganathan, A.,Gherasim, C.,Karasik, A.,Salchner, R.,Kieninger, C.,Wurst, K.,Banerjee, R.,Koutmos, M.,Krautler, B.; Antivitamin B12 Inhibition of the Human B12 -Processing Enzyme CblC: Crystal Structure of an Inactive Ternary Complex with Glutathione as the Cosubstrate.; Angew. Chem. Int. Ed. Engl., 56:7387-7392, 2017; PubMed: 28544088; DOI: 10.1002/anie.201701583

実験手法

X-RAY DIFFRACTION (2.51 Å)