5UMD
Structure of the Plasmodium falciparum 80S ribosome bound to the antimalarial drug mefloquine
This is a non-PDB format compatible entry.
Summary for 5UMD
Entry DOI | 10.2210/pdb5umd/pdb |
EMDB information | 8576 |
Descriptor | 28S ribosomal RNA, 60S ribosomal protein L7-3, putative, 60S ribosomal protein L13, putative, ... (48 entities in total) |
Functional Keywords | ribosome, protein synthesis, antimalarial |
Biological source | Plasmodium falciparum 3D7 More |
Total number of polymer chains | 45 |
Total formula weight | 2136615.67 |
Authors | Wong, W.,Bai, X.-C.,Brown, A.,Scheres, S.,Baum, J. (deposition date: 2017-01-27, release date: 2017-03-01, Last modification date: 2024-05-15) |
Primary citation | Wong, W.,Bai, X.C.,Sleebs, B.E.,Triglia, T.,Brown, A.,Thompson, J.K.,Jackson, K.E.,Hanssen, E.,Marapana, D.S.,Fernandez, I.S.,Ralph, S.A.,Cowman, A.F.,Scheres, S.H.,Baum, J. Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis. Nat Microbiol, 2:17031-17031, 2017 Cited by PubMed: 28288098DOI: 10.1038/nmicrobiol.2017.31 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.2 Å) |
Structure validation
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