5UII

structure of DHFR with bound buformin and NADP

Summary for 5UII

Entry DOI	10.2210/pdb5uii/pdb
Related	5UIH 5UIO 5UIP
Descriptor	Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CALCIUM ION, ... (6 entities in total)
Functional Keywords	dhfr, buformin, nadp, oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	19121.03
Authors	Pedersen, L.C.,London, R.E. (deposition date: 2017-01-14, release date: 2018-01-31, Last modification date: 2023-10-25)
Primary citation	Gabel, S.A.,Duff, M.R.,Pedersen, L.C.,DeRose, E.F.,Krahn, J.M.,Howell, E.E.,London, R.E. A Structural Basis for Biguanide Activity. Biochemistry, 56:4786-4798, 2017 Cited by PubMed: 28766937 DOI: 10.1021/acs.biochem.7b00619 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.351 Å)

Structure validation