5UII
structure of DHFR with bound buformin and NADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dihydrofolate reductase | polymer | 163 | 18157.3 | 1 | UniProt (P0ABQ4) Pfam (PF00186) | Escherichia coli | |
| 2 | B (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) PubChem (5885) PubChem (4412) PubChem (145946263) PubChem (153311489) PubChem (46936685) PubChem (165382010) PubChem (174001641) PubChem (71717786) PubChem (90473931) PubChem (91972139) | |||
| 3 | C (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) PubChem (271) | |||
| 4 | D (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 5 | E (A) | N-butyl-N'-(diaminomethylidene)guanidine | non-polymer | 157.2 | 1 | Chemie (BFR) PubChem (176521725) | |||
| 6 | F (A) | water | water | 18.0 | 201 | Chemie (HOH) |
Sequence modifications
A: 2 - 159 (UniProt: P0ABQ4)
| PDB | External Database | Details |
|---|---|---|
| Gly 1 | - | expression tag |
| Ser 152 | Cys 152 | engineered mutation |
| Gly 160 | - | expression tag |
| Gly 161 | - | expression tag |
| Gly 162 | - | expression tag |
| Gly 163 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 18157.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 963.7 | |
| All* | Total formula weight | 19121.0 |
