5UII
structure of DHFR with bound buformin and NADP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Dihydrofolate reductase | polymer | 163 | 18157.3 | 1 | UniProt (P0ABQ4) Pfam (PF00186) In PDB | Escherichia coli | |
2 | A | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
3 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
4 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
5 | A | N-butyl-N'-(diaminomethylidene)guanidine | non-polymer | 157.2 | 1 | Chemie (BFR) | |||
6 | water | water | 18.0 | 201 | Chemie (HOH) |
Sequence modifications
A: 2 - 159 (UniProt: P0ABQ4)
PDB | External Database | Details |
---|---|---|
Gly 1 | - | expression tag |
Ser 152 | Cys 152 | engineered mutation |
Gly 160 | - | expression tag |
Gly 161 | - | expression tag |
Gly 162 | - | expression tag |
Gly 163 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 18157.3 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 963.7 | |
All* | Total formula weight | 19121.0 |