5UHL

Crystal structure of the core catalytic domain of human O-GlcNAcase complexed with Thiamet G

5UHL の概要

• エントリーDOI: 10.2210/pdb5uhl/pdb
• 関連するPDBエントリー: 5UHK 5UHO 5UHp
• 分子名称: O-GlcNAcase TIM-barrel domain, O-GlcNAcase stalk domain, (2Z,3aR,5R,6S,7R,7aR)-2-(ethylimino)-5-(hydroxymethyl)hexahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol, ... (4 entities in total)
• 機能のキーワード: hydrolase, o-glcnacase, gh84, enzyme, thiamet g
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Isoform 3: Nucleus . Isoform 1: Cytoplasm : O60502 O60502
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 118044.43

構造登録者

Klein, D.J.,Elsen, N.L. (登録日: 2017-01-11, 公開日: 2017-03-29, 最終更新日: 2024-03-06)

• 主引用文献: Elsen, N.L.,Patel, S.B.,Ford, R.E.,Hall, D.L.,Hess, F.,Kandula, H.,Kornienko, M.,Lumb, K.J.,Reid, J.,Selnick, H.,Shipman, J.M.,Sharma, S.,Soisson, S.M.,Klein, D.J.; Crystal structure of the core catalytic domain of human O-GlcNAcase and molecular basis of activity and inhibition; To Be Published,

実験手法

X-RAY DIFFRACTION (3.14 Å)