5UGF

Crystal structure of human purine nucleoside phosphorylase (F159Y) mutant complexed with DADMe-ImmG and phosphate

5UGF の概要

• エントリーDOI: 10.2210/pdb5ugf/pdb
• 分子名称: Purine nucleoside phosphorylase, PHOSPHATE ION, 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, ... (4 entities in total)
• 機能のキーワード: phosphorylase, inhibitor, transition state analogue, purine salvage pathway, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 218819.84

構造登録者

Harijan, R.K.,Cameron, S.A.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (登録日: 2017-01-08, 公開日: 2017-06-21, 最終更新日: 2023-10-04)

• 主引用文献: Harijan, R.K.,Zoi, I.,Antoniou, D.,Schwartz, S.D.,Schramm, V.L.; Catalytic-site design for inverse heavy-enzyme isotope effects in human purine nucleoside phosphorylase.; Proc. Natl. Acad. Sci. U.S.A., 114:6456-6461, 2017; PubMed: 28584087; DOI: 10.1073/pnas.1704786114

実験手法

X-RAY DIFFRACTION (2.2 Å)