5UFI

DCN1 bound to DI-591

Summary for 5UFI

Entry DOI	10.2210/pdb5ufi/pdb
Related PRD ID	PRD_002263
Descriptor	DCN1-like protein 1, N-[(1S)-1-cyclohexyl-2-{[3-(morpholin-4-yl)propanoyl]amino}ethyl]-N~2~-propanoyl-3-[6-(propan-2-yl)-1,3-benzothiazol-2-yl]-L-alaninamide (3 entities in total)
Functional Keywords	e3 ligase, complex, ligase-inhibitor complex, ligase/inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q96GG9
Total number of polymer chains	4
Total formula weight	107350.66
Authors	Stuckey, J. (deposition date: 2017-01-04, release date: 2017-11-01, Last modification date: 2024-04-03)
Primary citation	Zhou, H.,Lu, J.,Liu, L.,Bernard, D.,Yang, C.Y.,Fernandez-Salas, E.,Chinnaswamy, K.,Layton, S.,Stuckey, J.,Yu, Q.,Zhou, W.,Pan, Z.,Sun, Y.,Wang, S. A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation. Nat Commun, 8:1150-1150, 2017 Cited by PubMed: 29074978 DOI: 10.1038/s41467-017-01243-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.58 Å)

Structure validation