5UE4

proMMP-9desFnII complexed to JNJ0966 INHIBITOR

Summary for 5UE4

• Entry DOI: 10.2210/pdb5ue4/pdb
• Related: 5UE3
• Descriptor: Matrix metalloproteinase-9, ZINC ION, CALCIUM ION, ... (6 entities in total)
• Functional Keywords: prommp9, zymogen, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted, extracellular space, extracellular matrix : P14780
• Total number of polymer chains: 2
• Total formula weight: 54136.11

Authors

Alexander, R.S.,Spurlino, J.,Milligan, C. (deposition date: 2016-12-29, release date: 2017-09-13, Last modification date: 2024-03-06)

• Primary citation: Scannevin, R.H.,Alexander, R.,Haarlander, T.M.,Burke, S.L.,Singer, M.,Huo, C.,Zhang, Y.M.,Maguire, D.,Spurlino, J.,Deckman, I.,Carroll, K.I.,Lewandowski, F.,Devine, E.,Dzordzorme, K.,Tounge, B.,Milligan, C.,Bayoumy, S.,Williams, R.,Schalk-Hihi, C.,Leonard, K.,Jackson, P.,Todd, M.,Kuo, L.C.,Rhodes, K.J.; Discovery of a highly selective chemical inhibitor of matrix metalloproteinase-9 (MMP-9) that allosterically inhibits zymogen activation.; J. Biol. Chem., 292:17963-17974, 2017; PubMed: 28860188; DOI: 10.1074/jbc.M117.806075

Experimental method

X-RAY DIFFRACTION (1.8 Å)