5UE2

proMMP-7 with heparin octasaccharide bridging between domains

5UE2 の概要

• エントリーDOI: 10.2210/pdb5ue2/pdb
• 関連するPDBエントリー: 2MZE
• NMR情報: BMRB: 25485
• 分子名称: Matrilysin, 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: glycan complex with protein, enzyme complex with heparin oligosaccharide, zymogen, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30128.01

構造登録者

Fulcher, Y.G.,Prior, S.H.,Linhardt, R.J.,Van Doren, S.R. (登録日: 2016-12-29, 公開日: 2017-07-19, 最終更新日: 2024-05-22)

• 主引用文献: Fulcher, Y.G.,Prior, S.H.,Masuko, S.,Li, L.,Pu, D.,Zhang, F.,Linhardt, R.J.,Van Doren, S.R.; Glycan Activation of a Sheddase: Electrostatic Recognition between Heparin and proMMP-7.; Structure, 25:1100-1110.e5, 2017; PubMed: 28648610; DOI: 10.1016/j.str.2017.05.019

実験手法

SOLUTION NMR