5UAN

Crystal structure of multi-domain RAR-beta-RXR-alpha heterodimer on DNA

Summary for 5UAN

Entry DOI	10.2210/pdb5uan/pdb
Descriptor	Retinoic acid receptor RXR-alpha, Retinoic acid receptor beta, Nuclear receptor coactivator 2, ... (8 entities in total)
Functional Keywords	nuclear receptors, transcription, protein-dna complex, transcription-dna complex, transcription/dna
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus : P19793 E7EWM1 Isoform Beta-1: Nucleus. Isoform Beta-2: Nucleus. Isoform Beta-4: Cytoplasm: P10826
Total number of polymer chains	6
Total formula weight	99768.27
Authors	Chandra, V.,Wu, D.,Kim, Y.,Rastinejad, F. (deposition date: 2016-12-19, release date: 2017-10-18, Last modification date: 2023-10-04)
Primary citation	Chandra, V.,Wu, D.,Li, S.,Potluri, N.,Kim, Y.,Rastinejad, F. The quaternary architecture of RAR beta-RXR alpha heterodimer facilitates domain-domain signal transmission. Nat Commun, 8:868-868, 2017 Cited by PubMed: 29021580 DOI: 10.1038/s41467-017-00981-y PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.508 Å)

Structure validation