5UAB

MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody

5UAB の概要

• エントリーDOI: 10.2210/pdb5uab/pdb
• 関連するPDBエントリー: 5UAD 5UAF
• 分子名称: Hepatocyte growth factor receptor, N-{6-[([1,2,4]triazolo[4,3-a]pyridin-3-yl)sulfanyl]imidazo[1,2-b]pyridazin-2-yl}cyclopropanecarboxamide, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: met, tyrosine kinase, inhibitor, antitumor, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39057.44

構造登録者

Hoffman, I.D.,Lawson, J.D. (登録日: 2016-12-19, 公開日: 2017-05-31, 最終更新日: 2024-03-06)

• 主引用文献: Farrell, P.J.,Matuszkiewicz, J.,Balakrishna, D.,Pandya, S.,Hixon, M.S.,Kamran, R.,Chu, S.,Lawson, J.D.,Okada, K.,Hori, A.,Mizutani, A.,Iwata, H.,de Jong, R.,Hibner, B.,Vincent, P.; MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody.; Mol. Cancer Ther., 16:1269-1278, 2017; PubMed: 28341789; DOI: 10.1158/1535-7163.MCT-16-0771

実験手法

X-RAY DIFFRACTION (1.9 Å)