5UAB
MET Tyrosine Kinase Inhibition Enhances the Antitumor Efficacy of an HGF Antibody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Hepatocyte growth factor receptor | polymer | 343 | 38578.5 | 1 | UniProt (P08581) Pfam (PF07714) In PDB | Homo sapiens (Human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
| 2 | A | N-{6-[([1,2,4]triazolo[4,3-a]pyridin-3-yl)sulfanyl]imidazo[1,2-b]pyridazin-2-yl}cyclopropanecarboxamide | non-polymer | 351.4 | 1 | Chemie (84M) | |||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | water | water | 18.0 | 158 | Chemie (HOH) |
Sequence modifications
A: 1024 - 1360 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Gly 1019 | - | expression tag |
| Ala 1020 | - | expression tag |
| Met 1021 | - | expression tag |
| Gly 1022 | - | expression tag |
| Ser 1023 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38578.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 478.9 | |
| All* | Total formula weight | 39057.4 |
