5U86
Structure of the Aquifex aeolicus LpxC/LPC-069 complex
Summary for 5U86
Entry DOI | 10.2210/pdb5u86/pdb |
Descriptor | UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION, N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzamide, ... (7 entities in total) |
Functional Keywords | lpxc lipid a antibiotic lps, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Aquifex aeolicus (strain VF5) |
Total number of polymer chains | 1 |
Total formula weight | 32417.52 |
Authors | Najeeb, J.,Lee, C.-J.,Zhou, P. (deposition date: 2016-12-13, release date: 2017-08-09, Last modification date: 2023-10-04) |
Primary citation | Lemaitre, N.,Liang, X.,Najeeb, J.,Lee, C.J.,Titecat, M.,Leteurtre, E.,Simonet, M.,Toone, E.J.,Zhou, P.,Sebbane, F. Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC. MBio, 8:-, 2017 Cited by PubMed: 28743813DOI: 10.1128/mBio.00674-17 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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