5U86

Structure of the Aquifex aeolicus LpxC/LPC-069 complex

5U86 の概要

• エントリーDOI: 10.2210/pdb5u86/pdb
• 分子名称: UDP-3-O-acyl-N-acetylglucosamine deacetylase, ZINC ION, N-[(2S,3S)-4,4-difluoro-3-hydroxy-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-4-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)benzamide, ... (7 entities in total)
• 機能のキーワード: lpxc lipid a antibiotic lps, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Aquifex aeolicus (strain VF5)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32417.52

構造登録者

Najeeb, J.,Lee, C.-J.,Zhou, P. (登録日: 2016-12-13, 公開日: 2017-08-09, 最終更新日: 2023-10-04)

• 主引用文献: Lemaitre, N.,Liang, X.,Najeeb, J.,Lee, C.J.,Titecat, M.,Leteurtre, E.,Simonet, M.,Toone, E.J.,Zhou, P.,Sebbane, F.; Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC.; MBio, 8:-, 2017; PubMed: 28743813; DOI: 10.1128/mBio.00674-17

実験手法

X-RAY DIFFRACTION (1.62 Å)