5U69

Polycomb protein EED in complex with inhibitor: (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine

5U69 の概要

• エントリーDOI: 10.2210/pdb5u69/pdb
• 関連するPDBエントリー: 5U6D
• 分子名称: Polycomb protein EED, (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine (3 entities in total)
• 機能のキーワード: wd40 prc2, protein binding, inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus: O75530
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42946.98

構造登録者

Jakob, C.G.,Zhu, H. (登録日: 2016-12-07, 公開日: 2017-03-15, 最終更新日: 2023-10-04)

• 主引用文献: Curtin, M.L.,Pliushchev, M.A.,Li, H.Q.,Torrent, M.,Dietrich, J.D.,Jakob, C.G.,Zhu, H.,Zhao, H.,Wang, Y.,Ji, Z.,Clark, R.F.,Sarris, K.A.,Selvaraju, S.,Shaw, B.,Algire, M.A.,He, Y.,Richardson, P.L.,Sweis, R.F.,Sun, C.,Chiang, G.G.,Michaelides, M.R.; SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.; Bioorg. Med. Chem. Lett., 27:1576-1583, 2017; PubMed: 28254486; DOI: 10.1016/j.bmcl.2017.02.030

実験手法

X-RAY DIFFRACTION (1.28 Å)