5U69

Polycomb protein EED in complex with inhibitor: (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016571	biological_process	histone methylation
A	0035098	cellular_component	ESC/E(Z) complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue LQD A 501

Chain	Residue
A	PHE97
A	HOH689
A	TYR148
A	GLU238
A	LEU240
A	MET256
A	ASP310
A	TYR365
A	ARG367
A	ARG414

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Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI

Chain	Residue	Details
A	LEU206-ILE220

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:20974918

Chain	Residue	Details
A	LYS197
A	LYS268
A	LYS284

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