5U0T
Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin in complex with (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-3-(methylamino)-alpha-D-glucopyranosyl]oxy}-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
Summary for 5U0T
Entry DOI | 10.2210/pdb5u0t/pdb |
Related | 5U0N 5U18 5U19 5U1E 5U1I |
Descriptor | Putative gentamicin methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-3-(methylamino)-alpha-D-glucopyranosyl]oxy}-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside, ... (5 entities in total) |
Functional Keywords | gentamicin methyltransferase, transferase |
Biological source | Micromonospora echinospora |
Total number of polymer chains | 1 |
Total formula weight | 38301.99 |
Authors | Bury, P.,Huang, F.,Leadlay, P.,Dias, M.V.B. (deposition date: 2016-11-27, release date: 2017-11-01, Last modification date: 2023-10-04) |
Primary citation | Bury, P.D.S.,Huang, F.,Li, S.,Sun, Y.,Leadlay, P.F.,Dias, M.V.B. Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis. ACS Chem. Biol., 12:2779-2787, 2017 Cited by PubMed: 28876898DOI: 10.1021/acschembio.7b00466 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.109 Å) |
Structure validation
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