5U0T
Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin in complex with (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-3-(methylamino)-alpha-D-glucopyranosyl]oxy}-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
A | 0032259 | biological_process | methylation |
A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 23 |
Details | binding site for residue SAH A 401 |
Chain | Residue |
A | GLY131 |
A | MET180 |
A | ASN194 |
A | PRO196 |
A | LEU207 |
A | LEU208 |
A | ILE214 |
A | 7QM402 |
A | HOH513 |
A | HOH527 |
A | HOH542 |
A | CYS132 |
A | HOH558 |
A | HOH569 |
A | HOH591 |
A | HOH613 |
A | GLY133 |
A | VAL136 |
A | LEU137 |
A | ASP152 |
A | VAL153 |
A | GLY178 |
A | ASP179 |
site_id | AC2 |
Number of Residues | 21 |
Details | binding site for residue 7QM A 402 |
Chain | Residue |
A | ASP95 |
A | VAL96 |
A | GLU98 |
A | ASP107 |
A | TRP110 |
A | GLU111 |
A | ASN194 |
A | SER195 |
A | PRO196 |
A | ASN198 |
A | LEU208 |
A | GLU209 |
A | ASN235 |
A | ARG281 |
A | SAH401 |
A | HOH531 |
A | HOH554 |
A | HOH565 |
A | HOH582 |
A | HOH588 |
A | HOH603 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue MG A 403 |
Chain | Residue |
A | GLU98 |
A | ASP206 |
A | HOH512 |
A | HOH556 |
A | HOH573 |
A | HOH609 |