5U0T

Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin in complex with (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-3-(methylamino)-alpha-D-glucopyranosyl]oxy}-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside

5U0T の概要

• エントリーDOI: 10.2210/pdb5u0t/pdb
• 関連するPDBエントリー: 5U0N 5U18 5U19 5U1E 5U1I
• 分子名称: Putative gentamicin methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-3-(methylamino)-alpha-D-glucopyranosyl]oxy}-2-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside, ... (5 entities in total)
• 機能のキーワード: gentamicin methyltransferase, transferase
• 由来する生物種: Micromonospora echinospora
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38301.99

構造登録者

Bury, P.,Huang, F.,Leadlay, P.,Dias, M.V.B. (登録日: 2016-11-27, 公開日: 2017-11-01, 最終更新日: 2023-10-04)

• 主引用文献: Bury, P.D.S.,Huang, F.,Li, S.,Sun, Y.,Leadlay, P.F.,Dias, M.V.B.; Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis.; ACS Chem. Biol., 12:2779-2787, 2017; PubMed: 28876898; DOI: 10.1021/acschembio.7b00466

実験手法

X-RAY DIFFRACTION (2.109 Å)